1. RFP : 매개체 전파 감염병 감시.예측 및 방제연구

2. 해당분과 : 2-1-4 과제

3. 과제명 : 중증열성혈소판감소증바이러스 (SFTSV)에 대한 인체감염모델 확립을 위한 최적의 실험동물 발굴 및 이를 이용한 백신/치료물질 유효성 검증모델 구축

4. 연구책임자 : 정혜원(충북대학교)

[Abstract]

Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) has a wide host range. Not only has it been found in humans, but also in many wild and domesticated animals. The infection of breeding deer on farms is a particularly worrisome public health concern due to the large amount of human contact and the diverse use of deer products, including raw blood. To investigate the prevalence of breeding domesticated deer, we examined the SFTSV infection rate on deer farms in South Korea from 2015 to 2017. Of the 215 collected blood samples, 0.9% (2/215) were found to be positive for viral RNA by PCR, and sequence analysis showed the highest homology with the KADGH human isolate. Both SFTSV-specific recombinant N and Gn protein-based ELISAs revealed that 14.0% (30/215) and 7.9% (17/215) of collected blood specimens were positive for SFTSV antibody. These results demonstrate that the breeding farm deer are exposed to SFTSV and could be a potential infection source for humans through direct contact or consumption of byproducts.